DMD # 44792 1 Development of a Carbon - 14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
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Development of a carbon-14 labeling approach to support disposition studies with a pegylated biologic.
Although it is widely accepted that one can extend the pharmacokinetic half-life of a therapeutic protein by covalent conjugation with polyethylene glycol (PEG), the disposition properties of such biologics have not yet been fully evaluated. Therefore, a novel [¹⁴C]-labeling method was developed that can be applied to a biologic conjugated with PEG through a maleimide-cysteine reaction. The met...
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تاریخ انتشار 2012